8:45 am
Registration & Morning Coffee
9:15 am Chair’s Opening Remarks
Developing Scalable Analytical Frameworks to Validate Bioprocessing & Characterize the End Product
9:30 am Evaluating the Efficiency of Each Step of Downstream Processing to Validate Decision Making
Synopsis
- Implementing in-process analytics to monitor efficiency
- Interpreting outputs to effectively deduce process efficiency and technique efficacy
- Understanding how to engineer processes in the context of the outputs
10:00 am Developing Assays to Characterize the Product in the Context of Commercialization
Synopsis
- Implementing scalable analytical frameworks to validate the product’s profile
- Identifying which impurities have been produced in the process, and whether this is consistent between batches
- Overcoming the cost burden of chromatography with novel techniques
10:30 am
Morning Networking Break & Scientific Poster Session
Synopsis
Learn from your peers about their latest scientific insights and gain up-to-date data from companies sharing their exciting work.
Contribute towards the conversation and share your cutting-edge research to you fellow downstream process development community to:
- Communicate your breakthrough discoveries to a vast audience of experts
- Learn how others are tackling similar challenges to you
Optimizing Purification to Achieve Sufficient Product Quality & Quantity at Scale
11:30 am Designing Processes That Balance Product Purity, Quality, & Yield to Ensure a Scalable and Commercially Viable DSP
Synopsis
- Establishing quantitative specifications for organoleptic properties of food proteins to guide process design and optimization
- Comparing different methods to improve product quality while maintaining yield and purity
- Effectively adapting existing processes for scaling partners
12:00 pm Concentrating the Supernatant with Cost-Effective Techniques That Maintain Product Integrity
Synopsis
- Validating the filtration membranes are correct for the purpose of the protein
- Cooling down the system to prevent denaturation of the protein
- Recovering the protein after the precipitation step to ensure to protein remains active and functiona
12:30 pm Roundable Discussion: Counteracting the Risk of Denaturing Thermosensitive Proteins & Damaging Cells During Downstream Processing with Equipment Selection to Maintain Functionality
Synopsis
- Ensuring that equipment selection guarantees the integrity of proteins and cells
- Understanding the factors that need to be mitigated against
- Discussing the cost burden of improper equipment selection
1:15 pm
Networking Lunch
Managing Relationships with Contract Manufacturing Facilities & Taking Ownership of Pilot Plants to Accelerate Product Development
2:15 pm CMO Matchmaking: Accelerated Path to “I Do”
Synopsis
- Assessing the technical and physical capacity of contract facilities
- Troubleshooting technical downstream processing challenges at a distance to prevent the outsourcing bottleneck
- Aligning manufacturers’ capabilities with commercial objectives
2:45 pm DSP Facilities & Engineering Considerations & Challenges from a Cultivated Meat Perspective
Synopsis
- The scale-up and right sizing requirement – how to ensure facilities are fit for purpose for the downstream and commercial scale perspective
- The constant balance between CAPEX, facility maintenance, quality and technical teams to ensure product quality and commercial viability
- SciFi Foods’ experience in DSP and lessons learned to date